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KMID : 1240020140180030106
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International Neurourology Journal
2014 Volume.18 No. 3 p.106 ~ p.114
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Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis
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Fiehn Oliver
Kim Ja-Young
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Abstract
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Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient’s quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.
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KEYWORD
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Interstitial cystitis, Metabolomics, Biological markers, Magnetic resonance spectroscopy, Mass spectrometry
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